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    puf-9 PUM-HD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    puf-9
    Official Full Name
    PUM-HD domain-containing protein
    Primary source
    WormBase:WBGene00004245
    Locus tag
    CELE_W06B11.2
    See related
    AllianceGenome:WB:WBGene00004245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA catabolic process and negative regulation of translation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including HSN; gonad; ventral nerve cord; vulval muscle; and vulval precursor cell. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Orthologous to several human genes including PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See puf-9 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (5841592..5845987)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DAF-16/FOXO Controlled, germline Tumor affecting Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Alpha-tubulin N-acetyltransferase 2 Neighboring gene HintN domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PUF-8, a C. elegans ortholog of the RNA-binding proteins PUM1 and PUM2, is required for robustness of the cell death fate. Xu J, et al. Development, 2023 Oct 1. PMID 37747106, Free PMC Article
    2. Characteristics and evolution of the PUF gene family in Bombyx mori and 27 other species. Zhang CD, et al. Mol Biol Rep, 2012 Jan. PMID 21598114
    3. The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1. Nolde MJ, et al. Dev Biol, 2007 May 15. PMID 17412319, Free PMC Article
    4. A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans. Hubstenberger A, et al. Dev Biol, 2012 Jun 15. PMID 22542599, Free PMC Article
    5. A PUF family portrait: 3'UTR regulation as a way of life. Wickens M, et al. Trends Genet, 2002 Mar. PMID 11858839

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in post-transcriptional regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PUM-HD domain-containing protein
    NP_508980.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5841592..5845987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076579.9 → NP_508980.2  PUM-HD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508980.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23191
      Conserved Domains (2) summary
      cd07920
      Location:339 → 663
      Pumilio; Pumilio-family RNA binding domain
      pfam09606
      Location:28 → 324
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    Nucleotide Protein
    Heading Accession and Version

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