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    pdhb-1 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 177108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdhb-1
    Official Full Name
    Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Primary source
    WormBase:WBGene00015413
    Locus tag
    CELE_C04C3.3
    See related
    AllianceGenome:WB:WBGene00015413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in several structures, including anal depressor muscle; body wall musculature; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pdhb-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (3399672..3403908)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Clusterin-associated protein 1 homolog Neighboring gene Neurotransmitter-gated ion-channel ligand binding domain protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic enzymes aldo-2 and pdhb-1 as potential epigenetic regulators during C. elegans embryogenesis. Ravanelli S, et al. MicroPubl Biol, 2024. PMID 38947245, Free PMC Article
    2. NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. Zhu D, et al. Sci Adv, 2020 Jul. PMID 32789178, Free PMC Article
    3. Analysis of acidic peptides with a matrix-assisted laser desorption/ionization mass spectrometry using positive and negative ion modes with additive monoammonium phosphate. Nabetani T, et al. Proteomics, 2006 Aug. PMID 16897684
    4. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article
    5. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pyruvate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    NP_500340.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3399672..3403908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067939.8 → NP_500340.1  Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500340.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44451
      Conserved Domains (3) summary
      cd07036
      Location:29 → 195
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PLN02683
      Location:11 → 347
      PLN02683; pyruvate dehydrogenase E1 component subunit beta
      pfam02780
      Location:218 → 341
      Transketolase_C; Transketolase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44451.2

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