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    tbc-8 Rab GTPase-activating protein tbc-8 [ Caenorhabditis elegans ]

    Gene ID: 176454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-8
    Official Full Name
    Rab GTPase-activating protein tbc-8
    Primary source
    WormBase:WBGene00008018
    Locus tag
    CELE_C38H2.1
    See related
    AllianceGenome:WB:WBGene00008018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables small GTPase binding activity. Involved in dense core granule maturation. Located in Golgi cisterna; cytosol; and early endosome. Is expressed in nervous system. Orthologous to several human genes including SGSM2 (small G protein signaling modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    18
    Sequence:
    Chromosome: III; NC_003281.10 (10364956..10373234)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Orotidine 5'-phosphate decarboxylase Neighboring gene ncRNA Neighboring gene Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Neighboring gene Wsv136

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans. Hannemann M, et al. PLoS Genet, 2012. PMID 22654674, Free PMC Article
    2. Deciphering complex genome rearrangements in C. elegans using short-read whole genome sequencing. Maroilley T, et al. Sci Rep, 2021 Sep 14. PMID 34521941, Free PMC Article
    3. Two Rab2 interactors regulate dense-core vesicle maturation. Ailion M, et al. Neuron, 2014 Apr 2. PMID 24698274, Free PMC Article
    4. Detection of broadly expressed neuronal genes in C. elegans. Ruvinsky I, et al. Dev Biol, 2007 Feb 15. PMID 17046742
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dense core granule maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab GTPase-activating protein tbc-8
    NP_001255072.1
    • Confirmed by transcript evidence
    NP_001255073.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10364956..10373234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268143.4 → NP_001255072.1  Rab GTPase-activating protein tbc-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      I2HA99, I2HAA0
      Conserved Domains (3) summary
      smart00164
      Location:670 → 869
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00593
      Location:177 → 237
      RUN; domain involved in Ras-like GTPase signaling
      cd15784
      Location:299 → 467
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins

    2. NM_001268144.3 → NP_001255073.1  Rab GTPase-activating protein tbc-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HA99
      Conserved Domains (2) summary
      smart00164
      Location:452 → 641
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:71 → 239
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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