lias-1 Lipoyl synthase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lias-1
Official Full Name: Lipoyl synthase, mitochondrial
Primary source: WormBase:WBGene00010809
Locus tag: CELE_M01F1.3
See related: AllianceGenome:WB:WBGene00010809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including body wall musculature; excretory cell; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lias-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (3503710..3505037, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M01F1.2 (e-PCR)
- UniSTS:320587

M01F1.3 (e-PCR)
- UniSTS:307810

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lipoate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoate synthase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipoate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Lipoyl synthase, mitochondrial

NP_497722.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3503710..3505037 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065321.9 → NP_497722.3 Lipoyl synthase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497722.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21452

Conserved Domains (3) summary

cd01335
Location:119 → 314

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

PLN02428
Location:20 → 352

PLN02428; lipoic acid synthase

pfam16881
Location:7 → 96

LIAS_N; N-terminal domain of lipoyl synthase of Radical_SAM family