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    ckb-2 Choline kinase B2 [ Caenorhabditis elegans ]

    Gene ID: 175565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ckb-2
    Official Full Name
    Choline kinase B2
    Primary source
    WormBase:WBGene00000512
    Locus tag
    CELE_B0285.9
    See related
    AllianceGenome:WB:WBGene00000512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables choline kinase activity. Involved in CDP-choline pathway and IRE1-mediated unfolded protein response. Predicted to be active in cytoplasm. Is expressed in several structures, including excretory gland cell; head mesodermal cell; intestine; pharyngeal gland cell; and uterine seam cell. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ckb-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (4367949..4370160)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Matrix non-peptidase homolog 1 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Choline kinase B1 Neighboring gene ncRNA Neighboring gene Putative choline kinase B3 Neighboring gene pseudo Neighboring gene Protein containing ALS2cr12 (ALS2CR12) signature

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription. Marza E, et al. EMBO Rep, 2015 Mar. PMID 25652260, Free PMC Article
    2. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Gee P, et al. Biochim Biophys Acta, 2003 May 30. PMID 12758145
    3. Small GTPase signaling and the unfolded protein response. Bouchecareilh M, et al. Methods Enzymol, 2011. PMID 21329809
    4. GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Caruso ME, et al. Mol Cell Biol, 2008 Jul. PMID 18458060, Free PMC Article
    5. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables choline kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in IRE1-mediated unfolded protein response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Choline kinase B2
    NP_497880.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4367949..4370160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065479.9 → NP_497880.2  Choline kinase B2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497880.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46559, Q8IS23
      Conserved Domains (2) summary
      PLN02236
      Location:30 → 358
      PLN02236; choline kinase
      cl21453
      Location:42 → 357
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46559.2

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