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    sds-22 Protein phosphatase 1 regulatory subunit SDS22 homolog [ Caenorhabditis elegans ]

    Gene ID: 174266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sds-22
    Official Full Name
    Protein phosphatase 1 regulatory subunit SDS22 homolog
    Primary source
    WormBase:WBGene00011637
    Locus tag
    CELE_T09A5.9
    See related
    AllianceGenome:WB:WBGene00011637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of centriole replication. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sds-22 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (7858401..7859753)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Chromo domain-containing protein cec-3 Neighboring gene Small integral membrane protein 26 Neighboring gene Spindle apparatus protein lin-5 Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. Peel N, et al. PLoS Genet, 2017 Jan. PMID 28103229, Free PMC Article
    2. IGLR-2, a Leucine-Rich Repeat Domain Containing Protein, Is Required for the Host Defense in Caenorhabditis elegans. Kuo CJ, et al. Front Immunol, 2020. PMID 33329523, Free PMC Article
    3. Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans. Kemp CA, et al. Genetics, 2007 May. PMID 17446307, Free PMC Article
    4. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in negative regulation of centriole replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein phosphatase 1 regulatory subunit SDS22 homolog
    NP_495653.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7858401..7859753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063252.6 → NP_495653.1  Protein phosphatase 1 regulatory subunit SDS22 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495653.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45969
      Conserved Domains (3) summary
      sd00033
      Location:40 → 59
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:104 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82 → 137
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45969.1

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