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    daf-15 Raptor N-terminal CASPase-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    daf-15
    Official Full Name
    Raptor N-terminal CASPase-like domain-containing protein
    Primary source
    WormBase:WBGene00000911
    Locus tag
    CELE_C10C5.6
    See related
    AllianceGenome:WB:WBGene00000911
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase activator activity and protein-macromolecule adaptor activity. Involved in dauer larval development; determination of adult lifespan; and regulation of autophagosome assembly. Part of TORC1 complex. Is expressed in several structures, including body wall musculature; excretory cell; hermaphrodite distal tip cell; intestine; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See daf-15 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    20
    Sequence:
    Chromosome: IV; NC_003282.8 (9386208..9394979)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene DUF4477 domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutants of Caenorhabditis elegans that form dauer-like larvae. Albert PS, et al. Dev Biol, 1988 Apr. PMID 3350212
    2. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. Honda Y, et al. J Aging Res, 2015. PMID 25789174, Free PMC Article
    3. Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans. Zang X, et al. J Genet Genomics, 2024 May. PMID 37951302
    4. Lysosome Inhibition Reduces Basal and Nutrient-Induced Fat Accumulation in Caenorhabditis elegans. Lu R, et al. Mol Cells, 2022 Sep 30. PMID 36058890, Free PMC Article
    5. Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans. Nakatani Y, et al. Eur J Nutr, 2018 Apr. PMID 28239780

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans.
      Title: Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans.
    2. Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.
      Title: Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TORC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TORC1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Raptor N-terminal CASPase-like domain-containing protein
    NP_001293857.1
    • Confirmed by transcript evidence
    NP_001293858.1
    • Confirmed by transcript evidence
    NP_001368188.1
    • Confirmed by transcript evidence
    NP_001379099.1
    • Confirmed by transcript evidence
    NP_501653.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9386208..9394979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380409.1 → NP_001368188.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q68TI8
      Conserved Domains (3) summary
      sd00044
      Location:834 → 866
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:1438 → 1495
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:92 → 246
      Raptor_N; Raptor N-terminal CASPase like domain

    2. NM_069252.7 → NP_501653.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEV7
      Conserved Domains (3) summary
      sd00044
      Location:810 → 842
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:1420 → 1477
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:68 → 222
      Raptor_N; Raptor N-terminal CASPase like domain

    3. NM_001306929.3 → NP_001293858.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293858.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FD39
      Conserved Domains (3) summary
      sd00044
      Location:813 → 845
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:1423 → 1480
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:68 → 225
      Raptor_N; Raptor N-terminal CASPase like domain

    4. NM_001392368.1 → NP_001379099.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF88
      Conserved Domains (3) summary
      sd00044
      Location:810 → 842
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:1414 → 1471
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:68 → 222
      Raptor_N; Raptor N-terminal CASPase like domain

    5. NM_001306928.3 → NP_001293857.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F588
      Conserved Domains (3) summary
      sd00044
      Location:813 → 845
      HEAT; HEAT repeat [structural motif]
      sd00039
      Location:1417 → 1474
      7WD40; WD40 repeat [structural motif]
      pfam14538
      Location:68 → 225
      Raptor_N; Raptor N-terminal CASPase like domain
    Nucleotide Protein
    Heading Accession and Version

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