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    glna-3 Putative glutaminase 3 [ Caenorhabditis elegans ]

    Gene ID: 172547, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glna-3
    Official Full Name
    Putative glutaminase 3
    Primary source
    WormBase:WBGene00009271
    Locus tag
    CELE_F30F8.2
    See related
    AllianceGenome:WB:WBGene00009271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Is expressed in head neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glna-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (7826442..7831629, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene NAM-associated domain-containing protein Neighboring gene Helicase ATP-binding domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene General receptor for phosphoinositides 1-associated scaffold protein 1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system. Watson JD, et al. BMC Genomics, 2008 Feb 19. PMID 18284693, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative glutaminase 3
    NP_492162.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7826442..7831629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059761.4 → NP_492162.1  Putative glutaminase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93650, Q95QP4
      Conserved Domains (4) summary
      cd00204
      Location:480 → 569
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:174 → 460
      Glutaminase; Glutaminase
      pfam13637
      Location:487 → 536
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:482 → 513
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93650.2

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