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    cpn-2 Calponin-homology (CH) domain-containing protein;Transgelin [ Caenorhabditis elegans ]

    Gene ID: 173424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpn-2
    Official Full Name
    Calponin-homology (CH) domain-containing protein;Transgelin
    Primary source
    WormBase:WBGene00000778
    Locus tag
    CELE_D1069.2
    See related
    AllianceGenome:WB:WBGene00000778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to be active in actin cytoskeleton. Orthologous to several human genes including TAGLN (transgelin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpn-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (337782..339250)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Claudin family protein Neighboring gene COP9 signalosome complex subunit 3;Hyccin Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calponin-homology (CH) domain-containing protein;Transgelin
    NP_001300527.1
    • Confirmed by transcript evidence
    NP_493713.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      337782..339250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061312.6 → NP_493713.2  Transgelin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493713.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44788
      Conserved Domains (3) summary
      COG5199
      Location:14 → 187
      SCP1; Calponin [Cytoskeleton]
      pfam00307
      Location:25 → 133
      CH; Calponin homology (CH) domain
      pfam00402
      Location:173 → 196
      Calponin; Calponin family repeat

    2. NM_001313598.3 → NP_001300527.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWU9
      Conserved Domains (1) summary
      COG5199
      Location:1 → 97
      SCP1; Calponin [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version

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