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    aph-2 Nicastrin [ Caenorhabditis elegans ]

    Gene ID: 172905, updated on 9-Dec-2024

    Summary

    Official Symbol
    aph-2
    Official Full Name
    Nicastrin
    Primary source
    WormBase:WBGene00000148
    Locus tag
    CELE_ZC434.6
    See related
    AllianceGenome:WB:WBGene00000148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including Notch signaling pathway; egg-laying behavior; and pharynx development. Located in plasma membrane. Is expressed in oocyte. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See aph-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (10340997..10345654)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DUF3421 domain-containing protein Neighboring gene DUF3421 domain-containing protein Neighboring gene glutamate--tRNA ligase Neighboring gene Cytochrome c oxidase assembly factor 6 homolog;PRORP domain-containing protein Neighboring gene putative arginine kinase ZC434.8 Neighboring gene ShKT domain-containing protein

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Notch receptor processing  
    involved_in Notch signaling pathway  
    involved_in Notch signaling pathway PubMed 
    involved_in cell fate commitment involved in pattern specification PubMed 
    involved_in egg-laying behavior PubMed 
    involved_in embryonic morphogenesis PubMed 
    involved_in pharynx development PubMed 
    involved_in protein processing  
    involved_in protein processing  
    Component Evidence Code Pubs
    part_of gamma-secretase complex PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    Nicastrin
    NP_001122563.1
    • Confirmed by transcript evidence
    NP_492712.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10340997..10345654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060311.4 → NP_492712.2  Nicastrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492712.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23316
      Conserved Domains (1) summary
      cd03881
      Location:171 → 500
      M28_Nicastrin; M28 Zn-Peptidase Nicastrin, a main component of gamma-secretase complex
    2. NM_001129091.3 → NP_001122563.1  Nicastrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5Z2T7
      Conserved Domains (1) summary
      cd03881
      Location:37 → 665
      M28_Nicastrin; M28 Zn-peptidase nicastrin, a main component of gamma-secretase complex
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