spd-1 Protein regulator of cytokinesis 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: spd-1
Official Full Name: Protein regulator of cytokinesis 1
Primary source: WormBase:WBGene00004952
Locus tag: CELE_Y34D9A.4
See related: AllianceGenome:WB:WBGene00004952
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables microtubule binding activity. Involved in several processes, including ciliary body morphogenesis; gonad development; and microtubule bundle formation involved in mitotic spindle midzone assembly. Located in microtubule; mitotic spindle midzone; and nucleus. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See spd-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (1030633..1033436, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

his phenotype therefore enabled us to identify factors promoting microtubule organization during anaphase, whose contributions are normally undetectable in wild-type worms; we found that SPD-1 (PRC1) bundles microtubules and KLP-18 (kinesin-12) likely sorts those bundles into a functional orientation capable of mediating chromosome segregation.
Title: Interplay between microtubule bundling and sorting factors ensures acentriolar spindle stability during C. elegans oocyte meiosis.
SPD-1-CYK-4 interaction through the CYK-4 C-terminal tail plays an important role in maintaining the mechanical integrity of the central spindle under tension
Title: Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle.
The microtubule-bundling protein SPD-1/MAP-65 and BMK-1/kinesin-5 act as a brake opposing the force generated by the spindle midzone during Caenorhabditis elegans mitosis.
Title: Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Y34D9A_151.a (e-PCR)
- UniSTS:322734

Y34D9A_151.b (e-PCR)
- UniSTS:324273

Y34D9A_151.d (e-PCR)
- UniSTS:324597

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ciliary body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule bundle formation involved in mitotic spindle midzone assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Protein regulator of cytokinesis 1

NP_490809.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1030633..1033436 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058408.7 → NP_490809.2 Protein regulator of cytokinesis 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490809.2

Status: REVIEWED

UniProtKB/TrEMBL

G5ED58

Conserved Domains (1) summary

pfam03999
Location:228 → 472

MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)