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    K07E3.4 formate--tetrahydrofolate ligase [ Caenorhabditis elegans ]

    Gene ID: 181064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    K07E3.4
    Official Full Name
    formate--tetrahydrofolate ligase
    Primary source
    WormBase:WBGene00019492
    Locus tag
    CELE_K07E3.4
    See related
    AllianceGenome:WB:WBGene00019492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and formate-tetrahydrofolate ligase activity. Predicted to be involved in tetrahydrofolate interconversion. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal aortic aneurysm; cleft lip; developmental cardiac valvular defect; and neural tube defect (multiple). Orthologous to several human genes including MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See K07E3.4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (8080868..8084018, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene methenyltetrahydrofolate cyclohydrolase Neighboring gene Protein vem-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans. Hammerquist AM, et al. Sci Rep, 2020 Nov 9. PMID 33168938, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formate--tetrahydrofolate ligase
    NP_509360.1
    • Confirmed by transcript evidence
    NP_509361.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8080868..8084018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076960.6 → NP_509361.1  formate--tetrahydrofolate ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21284, Q9TY04
      Conserved Domains (1) summary
      PLN02759
      Location:13 → 640
      PLN02759; Formate--tetrahydrofolate ligase

    2. NM_076959.8 → NP_509360.1  formate--tetrahydrofolate ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21284, Q9TY04
      Conserved Domains (1) summary
      PLN02759
      Location:13 → 640
      PLN02759; Formate--tetrahydrofolate ligase
    Nucleotide Protein
    Heading Accession and Version

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