U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pot-1 Protection of telomeres homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 181894, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pot-1
    Official Full Name
    Protection of telomeres homolog 1
    Primary source
    WormBase:WBGene00015105
    Locus tag
    CELE_B0280.10
    See related
    AllianceGenome:WB:WBGene00015105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables C-rich strand telomeric DNA binding activity. Involved in negative regulation of telomere maintenance via telomere lengthening and telomere maintenance. Located in chromosome, telomeric region. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pot-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (7131880..7133678, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Probable-ribose 5-phosphate isomerase Neighboring gene Uncharacterized protein Neighboring gene WH1 domain-containing protein Neighboring gene putative geranylgeranyl transferase type-2 subunit beta Neighboring gene K Homology domain-containing protein Neighboring gene ncRNA Neighboring gene Putative tyrosine-protein phosphatase B0280.11

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans. Yamamoto I, et al. Elife, 2021 Jan 21. PMID 33476260, Free PMC Article
    2. The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery. Ferreira HC, et al. J Cell Biol, 2013 Dec 9. PMID 24297748, Free PMC Article
    3. Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans. Lackner DH, et al. EMBO J, 2012 Apr 18. PMID 22425786, Free PMC Article
    4. Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways. Shtessel L, et al. G3 (Bethesda), 2013 Feb. PMID 23390606, Free PMC Article
    5. TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans. Manzato C, et al. Nucleic Acids Res, 2023 Oct 27. PMID 37713629, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.
      Title: TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.
    2. Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations.
      Title: Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations.
    3. The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
      Title: The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.
    4. POT-1 has a role in anchoring telomeres through SUN-1 at the nuclear periphery.
      Title: The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.
    5. A distinct role for POT-1 in C. elegans telomere biology, as deficiency for pot-1 but not pot-2 modestly enhanced the rate of telomere erosion in trt-1 mutants, suggesting a telomere capping function of POT-1.
      Title: Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables C-rich strand telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded telomeric DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomere lengthening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Protection of telomeres homolog 1
    NP_001348724.1
    • Partially confirmed by transcript evidence
    NP_001348725.1
    • Confirmed by transcript evidence
    NP_001348726.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7131880..7133678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361731.2 → NP_001348724.1  Protection of telomeres homolog 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A2K5ATS5, A0A2K5ATS9, A0A2K5ATU9, P42001
      UniProtKB/TrEMBL
      A0A7R7JK61

    2. NM_001361732.2 → NP_001348725.1  Protection of telomeres homolog 1 [Caenorhabditis elegans]

      Status: REVIEWED

    3. NM_001361730.1 → NP_001348726.1  Protection of telomeres homolog 1 [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42001.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools