K02F3.2 putative calcium-binding mitochondrial carrier K02F3.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K02F3.2
Official Full Name: putative calcium-binding mitochondrial carrier K02F3.2
Primary source: WormBase:WBGene00019326
Locus tag: CELE_K02F3.2
See related: AllianceGenome:WB:WBGene00019326
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acidic amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Asperger syndrome; adult-onset type II citrullinemia; autistic disorder; developmental and epileptic encephalopathy 39; and neonatal-onset type II citrullinemia. Orthologous to several human genes including SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See K02F3.2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (845841..851344)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02F3.2 (e-PCR)
- UniSTS:311375

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate-aspartate shuttle	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate-aspartate shuttle	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative calcium-binding mitochondrial carrier K02F3.2

NP_001263698.1

Confirmed by transcript evidence

NP_497274.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

845841..851344

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064873.6 → NP_497274.3 putative calcium-binding mitochondrial carrier K02F3.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497274.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21153

Conserved Domains (5) summary

PTZ00184
Location:135 → 237

PTZ00184; calmodulin; Provisional

PTZ00169
Location:374 → 648

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:561 → 650

Mito_carr; Mitochondrial carrier protein

pfam13833
Location:71 → 121

EF-hand_8; EF-hand domain pair

cl08302
Location:206 → 227

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001276769.4 → NP_001263698.1 putative calcium-binding mitochondrial carrier K02F3.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263698.1

Status: REVIEWED

UniProtKB/Swiss-Prot

L8E976, Q21153

Conserved Domains (5) summary

PTZ00184
Location:135 → 237

PTZ00184; calmodulin; Provisional

PTZ00169
Location:382 → 656

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:569 → 658

Mito_carr; Mitochondrial carrier protein

pfam13833
Location:71 → 121

EF-hand_8; EF-hand domain pair

cl08302
Location:206 → 227

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...