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    alg-4 Putative protein tag-76 [ Caenorhabditis elegans ]

    Gene ID: 176400, updated on 9-Dec-2024

    Summary

    Official Symbol
    alg-4
    Official Full Name
    Putative protein tag-76
    Primary source
    WormBase:WBGene00006449
    Locus tag
    CELE_ZK757.3
    See related
    AllianceGenome:WB:WBGene00006449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Involved in spermatogenesis. Predicted to be located in P granule. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See alg-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (9887210..9891424, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Snake toxin/toxin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ubiquitinyl hydrolase 1

    Bibliography

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA endonuclease activity  
    enables miRNA binding  
    enables nucleic acid binding  
    enables single-stranded RNA binding  
    Component Evidence Code Pubs
    located_in P granule PubMed 
    part_of RISC complex  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytoplasmic ribonucleoprotein granule  
    is_active_in nucleus  

    General protein information

    Preferred Names
    Putative protein tag-76
    NP_499191.1
    • Confirmed by transcript evidence
    NP_499192.1
    • Confirmed by transcript evidence
    NP_499193.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9887210..9891424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066790.5 → NP_499191.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681, Q7JMT0, Q9TW94
      Conserved Domains (5) summary
      PLN03202
      Location:67 → 959
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:374 → 484
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:530 → 964
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:266 → 306
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:89 → 235
      ArgoN; N-terminal domain of argonaute
    2. NM_066791.6 → NP_499192.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681
      Conserved Domains (5) summary
      PLN03202
      Location:64 → 956
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:371 → 481
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:527 → 961
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:263 → 303
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:86 → 232
      ArgoN; N-terminal domain of argonaute
    3. NM_066792.4 → NP_499193.1  Putative protein tag-76 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34681
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