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    dhps-1 Deoxyhypusine synthase [ Caenorhabditis elegans ]

    Gene ID: 174840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhps-1
    Official Full Name
    Deoxyhypusine synthase
    Primary source
    WormBase:WBGene00012460
    Locus tag
    CELE_Y17G7B.4
    See related
    AllianceGenome:WB:WBGene00012460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable deoxyhypusine synthase activity. Predicted to be involved in spermidine metabolic process. Predicted to be active in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhps-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (11993001..11998009)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BZIP domain-containing protein Neighboring gene B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene Activin_recp domain-containing protein;DUF281 domain-containing protein Neighboring gene DNA replication licensing factor MCM2 Neighboring gene Globin domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Fievet BT, et al. Nat Cell Biol, 2013 Jan. PMID 23242217, Free PMC Article
    2. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables deoxyhypusine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyhypusine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Deoxyhypusine synthase
    NP_496557.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11993001..11998009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064156.6 → NP_496557.1  Deoxyhypusine synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XXJ0
      Conserved Domains (1) summary
      pfam01916
      Location:52 → 359
      DS; Deoxyhypusine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXJ0.1

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