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    nuc-1 Deoxyribonuclease-2 [ Caenorhabditis elegans ]

    Gene ID: 181174, updated on 9-Dec-2024

    Summary

    Official Symbol
    nuc-1
    Official Full Name
    Deoxyribonuclease-2
    Primary source
    WormBase:WBGene00003828
    Locus tag
    CELE_C07B5.5
    See related
    AllianceGenome:WB:WBGene00003828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Acts upstream of or within with a positive effect on negative regulation of antimicrobial peptide production. Located in lysosome. Is expressed in body wall musculature; head; intestinal cell; and vulva. Orthologous to human DNASE2B (deoxyribonuclease 2 beta) and DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See nuc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (9539905..9542329)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Nucleolar protein 16;Translation initiation factor IF-2 Neighboring gene tRNA-Val

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables deoxyribonuclease II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deoxyribonuclease II activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deoxyribonuclease II activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_positive_effect negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    Deoxyribonuclease-2
    NP_509604.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9539905..9542329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077203.9NP_509604.1  Deoxyribonuclease-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17778
      Conserved Domains (3) summary
      cd09120
      Location:21191
      PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
      cd09121
      Location:238374
      PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
      pfam03265
      Location:24371
      DNase_II; Deoxyribonuclease II