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    zipt-15 Zinc transporter ZIP8 [ Caenorhabditis elegans ]

    Gene ID: 190312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zipt-15
    Official Full Name
    Zinc transporter ZIP8
    Primary source
    WormBase:WBGene00021936
    Locus tag
    CELE_Y55F3BL.2
    See related
    AllianceGenome:WB:WBGene00021936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monoatomic cation:bicarbonate symporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and zinc ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn and hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14) and SLC39A8 (solute carrier family 39 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zipt-15 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (807398..824954, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SRR1-like domain-containing protein Neighboring gene YqaE/Pmp3 family membrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity. Sue AC, et al. J Assist Reprod Genet, 2022 Jun. PMID 35501415, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Zinc transporter ZIP8
    NP_001294570.1
    • Confirmed by transcript evidence
    NP_001294572.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      807398..824954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307643.4 → NP_001294572.1  Zinc transporter ZIP8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PS08
      Conserved Domains (1) summary
      pfam02535
      Location:54 → 405
      Zip; ZIP Zinc transporter

    2. NM_001307641.3 → NP_001294570.1  Zinc transporter ZIP8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PCA8
      Conserved Domains (1) summary
      pfam02535
      Location:20 → 288
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version

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