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    csc-1 Chromosome segregation and cytokinesis defective protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csc-1
    Official Full Name
    Chromosome segregation and cytokinesis defective protein 1
    Primary source
    WormBase:WBGene00000804
    Locus tag
    CELE_Y48E1B.12
    See related
    AllianceGenome:WB:WBGene00000804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in mitotic cleavage furrow ingression and nuclear division. Located in condensed nuclear chromosome; meiotic spindle midzone; and mitotic spindle midzone. Is expressed in oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See csc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (13596955..13597947)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene FTH domain-containing protein Neighboring gene Caspase A subunit p16 Neighboring gene Glutathione S-transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. Romano A, et al. J Cell Biol, 2003 Apr 28. PMID 12707312, Free PMC Article
    2. Chromosome segregation: Aurora B gets Tousled. Richie CT, et al. Curr Biol, 2005 May 24. PMID 15916939
    3. The molecular requirements for cytokinesis. Glotzer M. Science, 2005 Mar 18. PMID 15774750
    4. "Holo"er than thou: chromosome segregation and kinetochore function in C. elegans. Maddox PS, et al. Chromosome Res, 2004. PMID 15289669
    5. Cell division. Oegema K, et al. WormBook, 2006 Jan 19. PMID 18050484, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cleavage furrow ingression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in meiotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chromosome segregation and cytokinesis defective protein 1
    NP_496856.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13596955..13597947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064455.7 → NP_496856.1  Chromosome segregation and cytokinesis defective protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496856.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45952
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45952.1

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