U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    crls-1 putative cardiolipin synthase (CMP-forming) [ Caenorhabditis elegans ]

    Gene ID: 184910, updated on 4-Jan-2025

    Summary

    Official Symbol
    crls-1
    Official Full Name
    putative cardiolipin synthase (CMP-forming)
    Primary source
    WormBase:WBGene00017763
    Locus tag
    CELE_F23H11.9
    See related
    AllianceGenome:WB:WBGene00017763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cardiolipin synthase (CMP-forming). Involved in cardiolipin biosynthetic process; regulation of cell population proliferation; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See crls-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (908330..909902, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit B Neighboring gene Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Neighboring gene Rho-GAP domain-containing protein Neighboring gene Deltamethrin resistance protein prag01 domain-containing protein Neighboring gene MYND-type domain-containing protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cardiolipin synthase (CMP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cardiolipin synthase (CMP-forming) IEA
    Inferred from Electronic Annotation
    more info
     
    enables cardiolipin synthase (CMP-forming) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiolipin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    putative cardiolipin synthase (CMP-forming)
    NP_001022547.1
    • Confirmed by transcript evidence
    NP_001379893.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      908330..909902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393270.1NP_001379893.1  putative cardiolipin synthase (CMP-forming) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01916, Q5F4V9
      Conserved Domains (1) summary
      PLN02794
      Location:56209
      PLN02794; cardiolipin synthase
    2. NM_001027376.6NP_001022547.1  putative cardiolipin synthase (CMP-forming) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01916
      Conserved Domains (1) summary
      cl00453
      Location:32215
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase