U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sur-7 SUppressor of activated let-60 Ras [ Caenorhabditis elegans ]

    Gene ID: 181707, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sur-7
    Official Full Name
    SUppressor of activated let-60 Ras
    Primary source
    WormBase:WBGene00006353
    Locus tag
    CELE_F01G12.2
    See related
    AllianceGenome:WB:WBGene00006353
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including cellular response to zinc ion; muscle cell cellular homeostasis; and positive regulation of Ras protein signal transduction. Located in endoplasmic reticulum membrane. Is expressed in several structures, including hypodermis; muscle cell; pharynx; tail; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sur-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (16376595..16380050)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acetylcholinesterase 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Collagen alpha-2(IV) chain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans. Sharma AK, et al. Front Physiol, 2023. PMID 37822680, Free PMC Article
    2. Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans. Zhang JJ, et al. J Lipid Res, 2017 Sep. PMID 28710073, Free PMC Article
    3. Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids. Casorla-Perez LA, et al. J Virol, 2022 Nov 23. PMID 36342299, Free PMC Article
    4. Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. Murphy JT, et al. PLoS Genet, 2011 Mar. PMID 21455490, Free PMC Article
    5. Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation. Fisher K, et al. Biol Open, 2013 Dec 15. PMID 24285704, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cellular response to zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein stability IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SUppressor of activated let-60 Ras
    NP_001379862.1
    • Product from WormBase gene class sur;
      Confirmed by transcript evidence
    NP_741942.1
    • Product from WormBase gene class sur;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16376595..16380050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392907.1 → NP_001379862.1  SUppressor of activated let-60 Ras [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZM3

    2. NM_171809.4 → NP_741942.1  SUppressor of activated let-60 Ras [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19096

    RNA

    1. NR_132551.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools