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    mig-21 Abnormal cell migration protein 21 [ Caenorhabditis elegans ]

    Gene ID: 184064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-21
    Official Full Name
    Abnormal cell migration protein 21
    Primary source
    WormBase:WBGene00003252
    Locus tag
    CELE_F01F1.13
    See related
    AllianceGenome:WB:WBGene00003252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable signaling receptor activity. Involved in several processes, including nervous system development; neuroblast migration; and regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane. Is expressed in QL; QR; and body wall musculature. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-21 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5876947..5878380, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PAP-associated domain-containing protein Neighboring gene MIF4G domain-containing protein Neighboring gene Fructose-bisphosphate aldolase 2 Neighboring gene ncRNA Neighboring gene COX assembly mitochondrial protein Neighboring gene SAC3/GANP/THP3 conserved domain-containing protein;SAC3_GANP domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans. Sundararajan L, et al. Genetics, 2012 Dec. PMID 23051647, Free PMC Article
    2. Genes regulating touch cell development in Caenorhabditis elegans. Du H, et al. Genetics, 2001 May. PMID 11333230, Free PMC Article
    3. The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration. Sundararajan L, et al. Dev Biol, 2014 Aug 15. PMID 24954154, Free PMC Article
    4. C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats. Buettner FF, et al. Mol Cell, 2013 Apr 25. PMID 23562325
    5. Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts. Ebbing A, et al. Development, 2019 Sep 25. PMID 31488562, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIG-21 and UNC-40 control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the two Q neuroblasts.
      Title: The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts.
    2. an inherent left-right asymmetry in the Q neuroblasts with regard to UNC-40, PTP-3, and MIG-21 function that results in posterior vs. anterior migration of neuroblasts
      Title: Transmembrane proteins UNC-40/DCC, PTP-3/LAR, and MIG-21 control anterior-posterior neuroblast migration with left-right functional asymmetry in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of left/right asymmetry in nervous system IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of left/right asymmetry in nervous system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuroblast migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Abnormal cell migration protein 21
    NP_001254933.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5876947..5878380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268004.4 → NP_001254933.2  Abnormal cell migration protein 21 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254933.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G1FC92, Q19092
      UniProtKB/TrEMBL
      M5FK96
      Conserved Domains (1) summary
      smart00209
      Location:65 → 105
      TSP1; Thrombospondin type 1 repeats
    Nucleotide Protein
    Heading Accession and Version

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