cpsf-2 putative cleavage and polyadenylation specificity factor subunit 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cpsf-2
Official Full Name: putative cleavage and polyadenylation specificity factor subunit 2
Primary source: WormBase:WBGene00017313
Locus tag: CELE_F09G2.4
See related: AllianceGenome:WB:WBGene00017313
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in anal depressor muscle; body wall musculature; hypodermis; and pharynx. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cpsf-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (7179172..7182858)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F09G2.4 (e-PCR)
- UniSTS:309631

F09G2.5 (e-PCR)
- UniSTS:309632

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IEA Inferred from Electronic Annotation more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative cleavage and polyadenylation specificity factor subunit 2

NP_504822.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

7179172..7182858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072421.5 → NP_504822.1 putative cleavage and polyadenylation specificity factor subunit 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504822.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17403

Conserved Domains (5) summary

smart01027
Location:242 → 368

Beta-Casp; Beta-Casp domain

COG1236
Location:10 → 376

YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]

pfam07521
Location:562 → 601

RMMBL; RNA-metabolizing metallo-beta-lactamase

pfam13299
Location:642 → 840

CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal

cd16293
Location:10 → 203

CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain