smc-6 Structural maintenance of chromosomes protein 6 homolog smc-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: smc-6
Official Full Name: Structural maintenance of chromosomes protein 6 homolog smc-6
Primary source: WormBase:WBGene00010056
Locus tag: CELE_F54D5.14
See related: AllianceGenome:WB:WBGene00010056
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Located in condensed nuclear chromosome and nucleoplasm. Is expressed in germ line. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See smc-6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (11578716..11582739)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results suggest that SMC-5/6 and HIM-6 can synergistically regulate recombination intermediate metabolism and suppress ectopic recombination by controlling chromosome architecture during meiosis.
Title: The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.
Data propose that SMC-5/6 promotes replication fork stability and facilitates recombination-dependent repair.
Title: Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54D5.14 (e-PCR)
- UniSTS:312618

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Structural maintenance of chromosomes protein 6 homolog smc-6

NP_496476.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11578716..11582739

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064075.9 → NP_496476.2 Structural maintenance of chromosomes protein 6 homolog smc-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496476.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG17

Conserved Domains (1) summary

cl25732
Location:75 → 1128

SMC_N; RecF/RecN/SMC N terminal domain