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    tram-1 Translocating chain-associated membrane protein [ Caenorhabditis elegans ]

    Gene ID: 177902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tram-1
    Official Full Name
    Translocating chain-associated membrane protein
    Primary source
    WormBase:WBGene00007696
    Locus tag
    CELE_C24F3.1
    See related
    AllianceGenome:WB:WBGene00007696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and protein insertion into ER membrane. Located in dendrite terminus; periciliary membrane compartment; and rough endoplasmic reticulum. Is expressed in body wall musculature. Orthologous to human TRAM1 (translocation associated membrane protein 1); TRAM1L1 (translocation associated membrane protein 1 like 1); and TRAM2 (translocation associated membrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tram-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (10219373..10221287, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma Neighboring gene ABC transporter domain-containing protein Neighboring gene Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene protein-tyrosine-phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1. Tedesco P, et al. Age (Dordr), 2008 Mar. PMID 19424872, Free PMC Article
    2. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Rolls MM, et al. Mol Biol Cell, 2002 May. PMID 12006669, Free PMC Article
    3. Innovative fluorescent probes for in vivo visualization of biomolecules in living Caenorhabditis elegans. Wang C, et al. Cytometry A, 2021 Jun. PMID 33638604
    4. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Canning P, et al. Cell Rep, 2018 Jan 23. PMID 29420175, Free PMC Article
    5. Interpreting the pathogenicity of Joubert syndrome missense variants in Caenorhabditis elegans. Lange KI, et al. Dis Model Mech, 2021 Jan 1. PMID 33234550, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periciliary membrane compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Translocating chain-associated membrane protein
    NP_501868.1
    • Confirmed by transcript evidence
    NP_501869.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10219373..10221287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069468.4 → NP_501869.1  Translocating chain-associated membrane protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3P5
      Conserved Domains (2) summary
      pfam03798
      Location:124 → 308
      TRAM_LAG1_CLN8; TLC domain
      pfam08390
      Location:53 → 119
      TRAM1; TRAM1-like protein

    2. NM_069467.7 → NP_501868.1  Translocating chain-associated membrane protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXK7
      Conserved Domains (2) summary
      pfam03798
      Location:124 → 310
      TRAM_LAG1_CLN8; TLC domain
      pfam08390
      Location:53 → 119
      TRAM1; TRAM1-like protein
    Nucleotide Protein
    Heading Accession and Version

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