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    scrm-2 Phospholipid scramblase [ Caenorhabditis elegans ]

    Gene ID: 191509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scrm-2
    Official Full Name
    Phospholipid scramblase
    Primary source
    WormBase:WBGene00014200
    Locus tag
    CELE_ZK1053.5
    See related
    AllianceGenome:WB:WBGene00014200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. Orthologous to several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scrm-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (13235348..13236663)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene SLC41A/MgtE integral membrane domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans. Venegas V, et al. Mol Biol Cell, 2007 Aug. PMID 17567952, Free PMC Article
    2. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Wang X, et al. Nat Cell Biol, 2007 May. PMID 17401362
    3. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Züllig S, et al. Curr Biol, 2007 Jun 5. PMID 17540571
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phospholipid scramblase
    NP_493321.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13235348..13236663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060920.2 → NP_493321.1  Phospholipid scramblase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEQ3
      Conserved Domains (1) summary
      cl02043
      Location:40 → 263
      LOR; LURP-one-related
    Nucleotide Protein
    Heading Accession and Version

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