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    abhd-5.1 Abhydrolase domain-containing protein abhd-5.1 [ Caenorhabditis elegans ]

    Gene ID: 183295, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abhd-5.1
    Official Full Name
    Abhydrolase domain-containing protein abhd-5.1
    Primary source
    WormBase:WBGene00016506
    Locus tag
    CELE_C37H5.2
    See related
    AllianceGenome:WB:WBGene00016506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carboxylic ester hydrolase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in lipid homeostasis and phosphatidic acid biosynthetic process. Predicted to be active in lipid droplet and mitochondrion. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B) and ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See abhd-5.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (4847653..4849838)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Coexpressed With Polycystins Neighboring gene Abhydrolase domain-containing protein abhd-5.2 Neighboring gene Annexin Neighboring gene Acetyltransferase;Acyl-coenzyme A thioesterase 8;RRM_2 domain-containing protein Neighboring gene Serpentine receptor class delta-32

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. Yang L, et al. EMBO Rep, 2020 Nov 5. PMID 33034119, Free PMC Article
    2. Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity. Arneaud SLB, et al. Aging Cell, 2022 Sep. PMID 35977034, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Abhydrolase domain-containing protein abhd-5.1
    NP_504299.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4847653..4849838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071898.5 → NP_504299.2  Abhydrolase domain-containing protein abhd-5.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504299.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91143
      Conserved Domains (3) summary
      pfam00561
      Location:72 → 321
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam12695
      Location:73 → 179
      Abhydrolase_5; Alpha/beta hydrolase family
      cl21453
      Location:219 → 274
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91143.2

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