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    aqp-1 Aquaporin [ Caenorhabditis elegans ]

    Gene ID: 174190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aqp-1
    Official Full Name
    Aquaporin
    Primary source
    WormBase:WBGene00000169
    Locus tag
    CELE_F32A5.5
    See related
    AllianceGenome:WB:WBGene00000169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables channel activity. Involved in defense response to Gram-negative bacterium; glycerol transmembrane transport; and innate immune response. Located in basolateral plasma membrane. Is expressed in intestine and pharynx. Orthologous to several human genes including AQP10 (aquaporin 10); AQP3 (aquaporin 3 (Gill blood group)); and AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aqp-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (7235828..7238349, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Chloride channel protein;Chloride channel protein clh-3 Neighboring gene Uncharacterized protein Neighboring gene Serine carboxypeptidase ctsa-3.1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Peroxisomal membrane protein PEX13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans. Fierro-González JC, et al. PLoS One, 2011 Jan 27. PMID 21304598, Free PMC Article
    2. Functional analysis of the aquaporin gene family in Caenorhabditis elegans. Huang CG, et al. Am J Physiol Cell Physiol, 2007 May. PMID 17229810
    3. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Lee SJ, et al. Cell Metab, 2009 Nov. PMID 19883616, Free PMC Article
    4. Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. Severance S, et al. PLoS Genet, 2010 Jul 29. PMID 20686661, Free PMC Article
    5. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Martins R, et al. Aging Cell, 2016 Apr. PMID 26643314, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the downregulation of aqp-1 involved in inhibiting the activities of life span-extending transcription factors
      Title: Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyol transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aquaporin
    NP_001367603.1
    • Confirmed by transcript evidence
    NP_495510.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7235828..7238349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063109.6 → NP_495510.1  Aquaporin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19949
      Conserved Domains (1) summary
      cd00333
      Location:33 → 272
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    2. NM_001381493.2 → NP_001367603.1  Aquaporin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG23
      Conserved Domains (1) summary
      cd00333
      Location:24 → 263
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version

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