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    nceh-1 Alpha/beta hydrolase fold-3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nceh-1
    Official Full Name
    Alpha/beta hydrolase fold-3 domain-containing protein
    Primary source
    WormBase:WBGene00012810
    Locus tag
    CELE_Y43F8A.3
    See related
    AllianceGenome:WB:WBGene00012810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in membrane. Orthologous to human AADAC (arylacetamide deacetylase); AADACL2 (arylacetamide deacetylase like 2); and NCEH1 (neutral cholesterol ester hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nceh-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (19377444..19381029)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Lipoprotein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene SoLute Carrier family Related Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease. Zhang S, et al. Hum Mol Genet, 2017 Oct 1. PMID 28934392, Free PMC Article
    2. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha/beta hydrolase fold-3 domain-containing protein
    NP_001256852.1
    • Confirmed by transcript evidence
    NP_001256853.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19377444..19381029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269924.3 → NP_001256853.1  Alpha/beta hydrolase fold-3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0IWV1
      Conserved Domains (2) summary
      COG0657
      Location:41 → 413
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam07859
      Location:124 → 387
      Abhydrolase_3; alpha/beta hydrolase fold

    2. NM_001269923.4 → NP_001256852.1  Alpha/beta hydrolase fold-3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWL5
      Conserved Domains (2) summary
      COG0657
      Location:41 → 424
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam07859
      Location:124 → 398
      Abhydrolase_3; alpha/beta hydrolase fold
    Nucleotide Protein
    Heading Accession and Version

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