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    aakb-1 Association with the SNF1 complex (ASC) domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aakb-1
    Official Full Name
    Association with the SNF1 complex (ASC) domain-containing protein
    Primary source
    WormBase:WBGene00010115
    Locus tag
    CELE_F55F3.1
    See related
    AllianceGenome:WB:WBGene00010115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including egg-laying apparatus; neurons; pharynx; rectal valve cell; and tail hypodermis. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1) and PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aakb-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (13755771..13758962)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SH3 domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene Nuclear hormone receptor family member nhr-71 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Carboxylic ester hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. Tullet JM, et al. PLoS Genet, 2014 Feb. PMID 24516399, Free PMC Article
    2. Differential requirements for STRAD in LKB1-dependent functions in C. elegans. Narbonne P, et al. Development, 2010 Feb. PMID 20110331
    3. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Narbonne P, et al. Nature, 2009 Jan 8. PMID 19052547
    4. Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis. Ha MK, et al. Proteomics, 2006 Jun. PMID 16673436
    5. A shift of the TOR adaptor from Rictor towards Raptor by semaphorin in C. elegans. Nukazuka A, et al. Nat Commun, 2011 Sep 27. PMID 21952218, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Association with the SNF1 complex (ASC) domain-containing protein
    NP_001366890.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13755771..13758962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381137.2 → NP_001366890.1  Association with the SNF1 complex (ASC) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUY2
      Conserved Domains (2) summary
      cd02859
      Location:58 → 138
      E_set_AMPKbeta_like_N; N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit
      pfam04739
      Location:202 → 268
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interaction domain
    Nucleotide Protein
    Heading Accession and Version

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