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    slcf-1 MFS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slcf-1
    Official Full Name
    MFS domain-containing protein
    Primary source
    WormBase:WBGene00010340
    Locus tag
    CELE_F59F5.1
    See related
    AllianceGenome:WB:WBGene00010340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Located in basolateral plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See slcf-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (10529294..10533040)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Lysophospholipid acyltransferase 7 Neighboring gene Arf-GAP domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Gut granule LOss Neighboring gene Protein kinase domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. μHigh resolution-magic-angle spinning NMR spectroscopy for metabolic phenotyping of Caenorhabditis elegans. Wong A, et al. Anal Chem, 2014 Jun 17. PMID 24897622
    2. Metabolomics analysis uncovers that dietary restriction buffers metabolic changes associated with aging in Caenorhabditis elegans. Pontoizeau C, et al. J Proteome Res, 2014 Jun 6. PMID 24819046, Free PMC Article
    3. [Metabolic homeostasis as the cornerstone of aging]. Terret C, et al. Med Sci (Paris), 2012 Mar. PMID 22480656
    4. Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Mouchiroud L, et al. Aging Cell, 2011 Feb. PMID 21040400
    5. AP-1 Recruits SMAP-1/SMAPs to the trans-Golgi Network to Promote Sorting in Polarized Epithelia. Wang S, et al. Front Cell Dev Biol, 2021. PMID 34901019, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MFS domain-containing protein
    NP_509762.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10529294..10533040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077361.5 → NP_509762.2  MFS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509762.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECR3
      Conserved Domains (2) summary
      cd06174
      Location:44 → 410
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:79 → 376
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version

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