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    ipla-6 PNPLA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ipla-6
    Official Full Name
    PNPLA domain-containing protein
    Primary source
    WormBase:WBGene00022233
    Locus tag
    CELE_Y73B6BL.4
    See related
    AllianceGenome:WB:WBGene00022233
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-independent phospholipase A2 activity. Predicted to be involved in arachidonate metabolic process. Predicted to be active in membrane. Is expressed in several structures, including head mesodermal cell; intestine; nervous system; pharynx; and reproductive system. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ipla-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (6337653..6340098)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 2 Neighboring gene Macrophage migration inhibitory factor Neighboring gene RRM domain-containing protein Neighboring gene DNA ligase ATP-dependent N-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. Morrison K, et al. J Biol Chem, 2012 Nov 9. PMID 23007400, Free PMC Article
    2. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PNPLA domain-containing protein
    NP_500969.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6337653..6340098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068568.8 → NP_500969.1  PNPLA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXR3
      Conserved Domains (1) summary
      cd07211
      Location:200 → 508
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8
    Nucleotide Protein
    Heading Accession and Version

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