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    ddx-10 ATP-dependent RNA helicase;ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx-10
    Official Full Name
    ATP-dependent RNA helicase;ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein
    Primary source
    WormBase:WBGene00021277
    Locus tag
    CELE_Y23H5B.6
    See related
    AllianceGenome:WB:WBGene00021277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in rRNA processing. Predicted to be located in P granule. Predicted to be active in nucleus. Orthologous to human DDX10 (DEAD-box helicase 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddx-10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (2489976..2497381)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial Neighboring gene Conserved secreted protein Neighboring gene Eukaryotic translation initiation factor 3 subunit I;Serine-threonine kinase receptor-associated protein Neighboring gene U3 small nucleolar RNA-associated protein 15 homolog Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1. Chen S, et al. Nat Commun, 2024 Feb 1. PMID 38302462, Free PMC Article
    2. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    3. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase;ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein
    NP_001293289.1
    • Confirmed by transcript evidence
    NP_001293290.1
    • Confirmed by transcript evidence
    NP_490989.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2489976..2497381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058588.6 → NP_490989.1  ATP-dependent RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490989.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N478
      Conserved Domains (4) summary
      COG0513
      Location:52 → 511
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00268
      Location:78 → 282
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:305 → 416
      Helicase_C; Helicase conserved C-terminal domain
      pfam13959
      Location:461 → 517
      DUF4217; Domain of unknown function (DUF4217)

    2. NM_001306360.3 → NP_001293289.1  ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293289.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACL9
      Conserved Domains (1) summary
      pfam13959
      Location:46 → 102
      DUF4217; Domain of unknown function (DUF4217)

    3. NM_001306361.3 → NP_001293290.1  ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293290.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ADT4
      Conserved Domains (1) summary
      pfam13959
      Location:7 → 63
      DUF4217; Domain of unknown function (DUF4217)
    Nucleotide Protein
    Heading Accession and Version

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