fahd-1 Oxaloacetate tautomerase fahd-1, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fahd-1
Official Full Name: Oxaloacetate tautomerase fahd-1, mitochondrial
Primary source: WormBase:WBGene00022798
Locus tag: CELE_ZK688.3
See related: AllianceGenome:WB:WBGene00022798
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acetylpyruvate hydrolase activity. Located in mitochondrion. Is expressed in body wall musculature; excretory canal; pharynx; and vulva. Orthologous to human FAHD1 (fumarylacetoacetate hydrolase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fahd-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (7892256..7894629)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In C. elegans loss of the FAHD1 ortholog FAHD-1 was reported to impair mitochondrial function, locomotion and egg-laying behavior, yet the underlying mechanisms remained unclear. Using tissue-specific rescue of fahd-1(-) worms, we find that these phenotypic abnormalities are at least in part due to fahd-1's function in neurons
Title: Modulation of serotonin signaling by the putative oxaloacetate decarboxylase FAHD-1 in Caenorhabditis elegans.
1. Together these data establish a role of fahd-1 to maintain mitochondrial function and consequently physical activity in nematodes.
Title: FAH domain containing protein 1 (FAHD-1) is required for mitochondrial function and locomotion activity in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK688.3 (e-PCR)
- UniSTS:316327

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acetylpyruvate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Oxaloacetate tautomerase fahd-1, mitochondrial

NP_498715.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7892256..7894629

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066314.7 → NP_498715.1 Oxaloacetate tautomerase fahd-1, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498715.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34673

Conserved Domains (2) summary

COG0179
Location:13 → 203

MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]

pfam01557
Location:15 → 204

FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family