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    nipa-1 Magnesium transporter NIPA2 [ Caenorhabditis elegans ]

    Gene ID: 175418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nipa-1
    Official Full Name
    Magnesium transporter NIPA2
    Primary source
    WormBase:WBGene00021820
    Locus tag
    CELE_Y53G8B.4
    See related
    AllianceGenome:WB:WBGene00021820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Involved in adult locomotory behavior. Located in neuronal cell body. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 6 and hereditary spastic paraplegia 6. Orthologous to several human genes including NIPAL1 (NIPA like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nipa-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (3112428..3127124, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene tRNA Neighboring gene tRNA Neighboring gene maleylacetoacetate isomerase Neighboring gene Detyrosinated tubulin alpha-3 chain Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a gain-of-function mechanism. Zhao J, et al. J Neurosci, 2008 Dec 17. PMID 19091982, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Magnesium transporter NIPA2
    NP_001040884.2
    • Confirmed by transcript evidence
    NP_001122733.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3112428..3127124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129261.2 → NP_001122733.1  Magnesium transporter NIPA2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4S7C7
      Conserved Domains (2) summary
      COG0697
      Location:104 → 180
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
      cl23754
      Location:54 → 349
      EamA; EamA-like transporter family

    2. NM_001047419.5 → NP_001040884.2  Magnesium transporter NIPA2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040884.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3KFD2
      Conserved Domains (1) summary
      cl23754
      Location:35 → 330
      EamA; EamA-like transporter family
    Nucleotide Protein
    Heading Accession and Version

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