ggtb-1 putative geranylgeranyl transferase type-2 subunit beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ggtb-1
Official Full Name: putative geranylgeranyl transferase type-2 subunit beta
Primary source: WormBase:WBGene00015099
Locus tag: CELE_B0280.1
See related: AllianceGenome:WB:WBGene00015099
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable small GTPase binding activity and zinc ion binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Involved in PERK-mediated unfolded protein response. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Is expressed in head; intestine; nervous system; and tail. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ggtb-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (7133766..7136525)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0280.1 (e-PCR)
- UniSTS:308363

B0280.10 (e-PCR)
- UniSTS:313013

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to Rab geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rab geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables Rab geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in PERK-mediated unfolded protein response	HEP more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein geranylgeranylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Rab-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rab-protein geranylgeranyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: putative geranylgeranyl transferase type-2 subunit beta

NP_498559.1

Confirmed by transcript evidence

NP_741214.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7133766..7136525

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066158.9 → NP_498559.1 putative geranylgeranyl transferase type-2 subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498559.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41992, Q2V4X4

Conserved Domains (2) summary

PLN03201
Location:23 → 319

PLN03201; RAB geranylgeranyl transferase beta-subunit; Provisional

cd02894
Location:24 → 307

GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...
NM_171183.6 → NP_741214.2 putative geranylgeranyl transferase type-2 subunit beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741214.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P41992

Conserved Domains (1) summary

cd02894
Location:24 → 292

GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...