U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    knl-2 Kinetochore null protein 2 [ Caenorhabditis elegans ]

    Gene ID: 172350, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    knl-2
    Official Full Name
    Kinetochore null protein 2
    Primary source
    WormBase:WBGene00019432
    Locus tag
    CELE_K06A5.4
    See related
    AllianceGenome:WB:WBGene00019432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell division; chromosome segregation; and meiotic cell cycle. Located in kinetochore and nucleus. Orthologous to human MIS18BP1 (MIS18 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See knl-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6460878..6464286)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ras-related protein Rab-10 Neighboring gene ncRNA Neighboring gene Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene Major sperm protein Neighboring gene DUF389 domain membrane protein Neighboring gene M-phase inducer phosphatase cdc-25.1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transgenerational inheritance of centromere identity requires the CENP-A N-terminal tail in the C. elegans maternal germ line. Prosée RF, et al. PLoS Biol, 2021 Jul. PMID 34228701, Free PMC Article
    2. The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly. de Groot C, et al. Mol Biol Cell, 2021 Jun 1. PMID 33852350, Free PMC Article
    3. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. Maddox PS, et al. J Cell Biol, 2007 Mar 12. PMID 17339379, Free PMC Article
    4. Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans. Wenda JM, et al. J Cell Sci, 2021 Dec 1. PMID 34734636, Free PMC Article
    5. Initiation of Meiotic Development Is Controlled by Three Post-transcriptional Pathways in Caenorhabditis elegans. Mohammad A, et al. Genetics, 2018 Aug. PMID 29941619, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.
      Title: Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.
    2. The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly.
      Title: The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly.
    3. RbAp46/48LIN-53 localizes to the centromere during metaphase in a CENP-A (HCP-3)- and M18BP1KNL-2-dependent manner, suggesting CENP-A loading may occur before anaphase.
      Title: RbAp46/48(LIN-53) Is Required for Holocentromere Assembly in Caenorhabditis elegans.
    4. KNL-2 is specifically required for CENP-A incorporation into chromatin.
      Title: Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Kinetochore null protein 2
    NP_001367697.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6460878..6464286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380547.1 → NP_001367697.1  Kinetochore null protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44548
      Conserved Domains (3) summary
      PTZ00121
      Location:394 → 729
      PTZ00121; MAEBL; Provisional
      PRK12678
      Location:339 → 509
      PRK12678; transcription termination factor Rho; Provisional
      pfam09133
      Location:20 → 108
      SANTA; SANTA (SANT Associated)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44548.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools