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    nex-2 Annexin [ Caenorhabditis elegans ]

    Gene ID: 176446, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nex-2
    Official Full Name
    Annexin
    Primary source
    WormBase:WBGene00003589
    Locus tag
    CELE_T07C4.9
    See related
    AllianceGenome:WB:WBGene00003589
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables heparan sulfate proteoglycan binding activity; heparin binding activity; and phospholipid binding activity. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in pharynx. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23; autoimmune disease of the nervous system; inclusion body myopathy and brain white matter abnormalities; myocardial infarction; and systemic scleroderma. Orthologous to several human genes including ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nex-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (10325626..10330422, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Neighboring gene Short coiled-coil protein;Short coiled-coil protein homolog Neighboring gene Spindle assembly abnormal protein 7 Neighboring gene COMM domain-containing protein Neighboring gene JmjC domain-containing protein Neighboring gene ncRNA Neighboring gene Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation. Sugioka K, et al. Elife, 2017 Jan 16. PMID 28092264, Free PMC Article
    2. Identification, localization, and functional implications of an abundant nematode annexin. Creutz CE, et al. J Cell Biol, 1996 Mar. PMID 8601586, Free PMC Article
    3. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
    4. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974
    5. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparan sulfate proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Annexin
    NP_001022755.1
    • Confirmed by transcript evidence
    NP_001022756.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10325626..10330422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027585.6 → NP_001022756.1  Annexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMT5
      Conserved Domains (1) summary
      pfam00191
      Location:225 → 290
      Annexin; Annexin

    2. NM_001027584.7 → NP_001022755.1  Annexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27512
      Conserved Domains (1) summary
      pfam00191
      Location:267 → 332
      Annexin; Annexin
    Nucleotide Protein
    Heading Accession and Version

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