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    fkh-2 Forkhead box protein fkh-2 [ Caenorhabditis elegans ]

    Gene ID: 180663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkh-2
    Official Full Name
    Forkhead box protein fkh-2
    Primary source
    WormBase:WBGene00001434
    Locus tag
    CELE_T14G12.4
    See related
    AllianceGenome:WB:WBGene00001434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity. Involved in several processes, including neuron differentiation; non-motile cilium assembly; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including AWB; D; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Orthologous to several human genes including FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fkh-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (3740207..3742323, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene t-SNARE protein aex-4 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of FKH-2/FOXG1 is neuroprotective in a C. elegans model of Machado-Joseph disease. Fardghassemi Y, et al. Exp Neurol, 2021 Mar. PMID 33290777
    2. Induction of protective response to polystyrene nanoparticles associated with dysregulation of intestinal long non-coding RNAs in Caenorhabditis elegans. Zhao Y, et al. Ecotoxicol Environ Saf, 2021 Apr 1. PMID 33517035
    3. Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues. Molin L, et al. Development, 2000 Nov. PMID 11044397
    4. Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans. Mukhopadhyay S, et al. EMBO J, 2007 Jun 20. PMID 17510633, Free PMC Article
    5. The forkhead gene family of Caenorhabditis elegans. Hope IA, et al. Gene, 2003 Jan 30. PMID 12568714

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of FKH-2/FOXG1 is neuroprotective in a C. elegans model of Machado-Joseph disease.
      Title: Overexpression of FKH-2/FOXG1 is neuroprotective in a C. elegans model of Machado-Joseph disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Forkhead box protein fkh-2
    NP_001379595.1
    • Confirmed by transcript evidence
    NP_508644.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3740207..3742323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076243.9 → NP_508644.1  Forkhead box protein fkh-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22510, Q95QA9
      Conserved Domains (1) summary
      cd00059
      Location:93 → 170
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    2. NM_001392750.1 → NP_001379595.1  Forkhead box protein fkh-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl00061
      Location:1 → 69
      FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22510.1

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