daf-3 Smad protein daf-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: daf-3
Official Full Name: Smad protein daf-3
Primary source: WormBase:WBGene00000899
Locus tag: CELE_F25E2.5
See related: AllianceGenome:WB:WBGene00000899
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; determination of adult lifespan; and positive regulation of dauer larval development. Located in condensed chromosome; cytoplasm; and nucleus. Is expressed in several structures, including P1; P10; hermaphrodite distal tip cell; hypodermal cell; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See daf-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (817922..825475, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptomic Profiling of DAF-7/TGFbeta Pathway Mutants in C. elegans.
Title: Transcriptomic Profiling of DAF-7/TGFβ Pathway Mutants in C. elegans.
isolated dauer-formation mutations in C. briggsae, a species closely related to the model organism C. elegans and identified mutations in orthologs of C. elegans genes daf-2, daf-3 and daf-4
Title: Genetic analysis of dauer formation in Caenorhabditis briggsae.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25E2.5 (e-PCR)
- UniSTS:306203

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to pheromone	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Smad protein daf-3

NP_001024604.1

Confirmed by transcript evidence

NP_001024605.1

Partially confirmed by transcript evidence

NP_001300341.1

Confirmed by transcript evidence

NP_001300342.1

Confirmed by transcript evidence

NP_001300343.1

Confirmed by transcript evidence

NP_001300344.1

Confirmed by transcript evidence

NP_001300346.1

Confirmed by transcript evidence

NP_001368578.1

Confirmed by transcript evidence

NP_508161.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

817922..825475 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075760.6 → NP_508161.3 Smad protein daf-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508161.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3ASQ1, A0A0K3ATA0, A0A0K3AVK9, A0A0K3AVL3, A0A0K3AWB3, A0A0K3AYJ4, O17532, Q95QI7, Q95QI8

Conserved Domains (3) summary

smart00524
Location:656 → 857

DWB; Domain B in dwarfin family proteins

cd10492
Location:218 → 343

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

pfam03154
Location:367 → 557

Atrophin-1; Atrophin-1 family
NM_001029434.5 → NP_001024605.1 Smad protein daf-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024605.1

Status: REVIEWED

UniProtKB/TrEMBL

O17532

Conserved Domains (2) summary

smart00524
Location:560 → 761

DWB; Domain B in dwarfin family proteins

cd10492
Location:122 → 247

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
NM_001313414.4 → NP_001300343.1 Smad protein daf-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWB3

Conserved Domains (2) summary

smart00524
Location:622 → 823

DWB; Domain B in dwarfin family proteins

cd10492
Location:184 → 309

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
NM_001313413.4 → NP_001300342.1 Smad protein daf-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ASQ1

Conserved Domains (2) summary

smart00524
Location:625 → 826

DWB; Domain B in dwarfin family proteins

cd10492
Location:184 → 312

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
NM_001029433.7 → NP_001024604.1 Smad protein daf-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024604.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95QI8

Conserved Domains (2) summary

smart00524
Location:628 → 829

DWB; Domain B in dwarfin family proteins

cl00055
Location:184 → 315

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001313412.4 → NP_001300341.1 Smad protein daf-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVK9

Conserved Domains (2) summary

smart00524
Location:659 → 860

DWB; Domain B in dwarfin family proteins

cd10492
Location:218 → 346

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
NM_001380898.1 → NP_001368578.1 Smad protein daf-3 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

smart00524
Location:544 → 745

DWB; Domain B in dwarfin family proteins

cd10492
Location:106 → 231

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

pfam03154
Location:255 → 445

Atrophin-1; Atrophin-1 family
NM_001313415.4 → NP_001300344.1 Smad protein daf-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AYJ4

Conserved Domains (3) summary

smart00524
Location:547 → 748

DWB; Domain B in dwarfin family proteins

cl00055
Location:106 → 234

MH1; N-terminal Mad Homology 1 (MH1) domain

pfam07223
Location:249 → 439

DUF1421; Protein of unknown function (DUF1421)
NM_001313417.4 → NP_001300346.1 Smad protein daf-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVL3

Conserved Domains (1) summary

smart00524
Location:47 → 248

DWB; Domain B in dwarfin family proteins