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    npr-17 putative G-protein coupled receptor C06G4.5 [ Caenorhabditis elegans ]

    Gene ID: 176124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npr-17
    Official Full Name
    putative G-protein coupled receptor C06G4.5
    Primary source
    WormBase:WBGene00015559
    Locus tag
    CELE_C06G4.5
    See related
    AllianceGenome:WB:WBGene00015559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in ganglia and head neurons. Orthologous to human SSTR4 (somatostatin receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npr-17 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (7990715..7996453, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Calpain clp-1 Neighboring gene KH domain-containing protein C06G4.1 Neighboring gene Uncharacterized protein Neighboring gene Cyclin-T1.1 Neighboring gene Cyclin-T1.2 Neighboring gene Lipid droplet-regulating VLDL assembly factor AUP1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders. Katner SN, et al. Behav Brain Res, 2019 Jun 3. PMID 30802531, Free PMC Article
    2. Food preference-based screening method for identification of effectors of substance use disorders using Caenorhabditis elegans. Kim AT, et al. Life Sci, 2024 May 15. PMID 38514005
    3. Caenorhabditis Elegans Exhibits Morphine Addiction-like Behavior via the Opioid-like Receptor NPR-17. Ide S, et al. Front Pharmacol, 2021. PMID 35046825, Free PMC Article
    4. An opioid-like system regulating feeding behavior in C. elegans. Cheong MC, et al. Elife, 2015 Apr 21. PMID 25898004, Free PMC Article
    5. The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission. Harris G, et al. J Neurosci, 2010 Jun 9. PMID 20534837, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caenorhabditis elegans has an endogenous opioid system that acts through NPR-17.
      Title: An opioid-like system regulating feeding behavior in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative G-protein coupled receptor C06G4.5
    NP_498743.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7990715..7996453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066342.5 → NP_498743.2  putative G-protein coupled receptor C06G4.5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498743.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34311
      Conserved Domains (2) summary
      pfam00001
      Location:71 → 339
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:61 → 191
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34311.3

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