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    T13F2.2 Putative RNA polymerase II transcriptional coactivator [ Caenorhabditis elegans ]

    Gene ID: 188475, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T13F2.2
    Official Full Name
    Putative RNA polymerase II transcriptional coactivator
    Primary source
    WormBase:WBGene00011743
    Locus tag
    CELE_T13F2.2
    See related
    AllianceGenome:WB:WBGene00011743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables transcription coactivator activity. Involved in RNA polymerase II promoter clearance. Predicted to be located in nucleus. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T13F2.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (9796688..9797354, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FTH domain-containing protein Neighboring gene BRCT domain-containing protein Neighboring gene Delta(5) fatty acid desaturase fat-4 Neighboring gene Delta(6)-fatty-acid desaturase fat-3;Fatty acid desaturase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE. Akimoto Y, et al. Genes Cells, 2014 Dec. PMID 25308091
    2. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II promoter clearance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative RNA polymerase II transcriptional coactivator
    NP_501750.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9796688..9797354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069349.7 → NP_501750.1  Putative RNA polymerase II transcriptional coactivator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94045
      Conserved Domains (1) summary
      pfam02229
      Location:69 → 116
      PC4; Transcriptional Coactivator p15 (PC4)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94045.1

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