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    rbm-28 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rbm-28
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00011043
    Locus tag
    CELE_R05H10.2
    See related
    AllianceGenome:WB:WBGene00011043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be active in nucleolus. Is expressed in several structures, including anal depressor muscle; excretory cell; pharynx; reproductive system; and tail. Used to study alopecia, neurologic defects, and endocrinopathy syndrome. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rbm-28 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (14857259..14866594)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene Glutathione peroxidase;Glutathione peroxidase 2 Neighboring gene Dot/Icm T4SS effector;Non-specific serine/threonine protein kinase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans. Bracht JR, et al. Dev Biol, 2010 Dec 15. PMID 20937268, Free PMC Article
    2. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Hayes GD, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381276
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_497077.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14857259..14866594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064676.7 → NP_497077.2  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497077.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62325
      Conserved Domains (4) summary
      COG0724
      Location:36 → 172
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12414
      Location:96 → 173
      RRM2_RBM28_like; RNA recognition motif 2 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12415
      Location:263 → 340
      RRM3_RBM28_like; RNA recognition motif 3 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12416
      Location:411 → 503
      RRM4_RBM28_like; RNA recognition motif 4 in RNA-binding protein 28 (RBM28) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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