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    C27A7.3 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 [ Caenorhabditis elegans ]

    Gene ID: 179665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C27A7.3
    Official Full Name
    Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3
    Primary source
    WormBase:WBGene00007755
    Locus tag
    CELE_C27A7.3
    See related
    AllianceGenome:WB:WBGene00007755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity and metal ion binding activity. Predicted to be located in membrane. Predicted to be active in I band and striated muscle dense body. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1); ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2); and ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C27A7.3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (12140925..12144293)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein Neighboring gene pseudo Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ShKT domain-containing protein;Thrombospondin type 1 domain protein Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3
    NP_001041087.1
    • Partially confirmed by transcript evidence
    NP_001041088.1
    • Partially confirmed by transcript evidence
    NP_001256406.1
    • Confirmed by transcript evidence
    NP_001256407.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12140925..12144293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269477.4 → NP_001256406.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W744
      Conserved Domains (2) summary
      pfam01663
      Location:81 → 386
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:79 → 426
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    2. NM_001047622.3 → NP_001041087.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041087.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90755, Q1NZ14
      Conserved Domains (2) summary
      pfam01663
      Location:81 → 386
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:79 → 426
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    3. NM_001269478.3 → NP_001256407.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W745
      Conserved Domains (2) summary
      pfam01663
      Location:51 → 356
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:49 → 396
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

    4. NM_001047623.4 → NP_001041088.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041088.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90755
      Conserved Domains (2) summary
      pfam01663
      Location:51 → 356
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:49 → 396
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90755.3

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