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    C04F12.8 Protein-tyrosine-phosphatase [ Caenorhabditis elegans ]

    Gene ID: 182228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C04F12.8
    Official Full Name
    Protein-tyrosine-phosphatase
    Primary source
    WormBase:WBGene00007302
    Locus tag
    CELE_C04F12.8
    See related
    AllianceGenome:WB:WBGene00007302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in striated muscle myosin thick filament. Orthologous to human DUSP14 (dual specificity phosphatase 14); DUSP18 (dual specificity phosphatase 18); and DUSP21 (dual specificity phosphatase 21). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C04F12.8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (9697237..9699566, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Membrane-associated protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in striated muscle myosin thick filament HDA PubMed 

    General protein information

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    Preferred Names
    Protein-tyrosine-phosphatase
    NP_492580.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9697237..9699566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060179.3 → NP_492580.2  Protein-tyrosine-phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492580.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVE7
      Conserved Domains (1) summary
      cd00127
      Location:10 → 145
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version

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