tba-1 Tubulin alpha chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tba-1
Official Full Name: Tubulin alpha chain
Primary source: WormBase:WBGene00006528
Locus tag: CELE_F26E4.8
See related: AllianceGenome:WB:WBGene00006528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in embryo development; establishment of mitotic spindle orientation; and regulation of cytokinesis. Located in several cellular components, including dendrite; neuronal cell body; and spindle. Is expressed in several structures, including ganglia; germ line; intestine; neurons; and somatic nervous system. Orthologous to human TUBAL3 (tubulin alpha like 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tba-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (9785781..9787624, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

tba-1(ju89) is an altered function allele that most likely perturbs interactions between TBA-1 and specific microtubule-associated proteins that control microtubule dynamics and transport of components needed for synapse and axon growth
Title: Motor neuron synapse and axon defects in a C. elegans alpha-tubulin mutant.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26E4.8 (e-PCR)
- UniSTS:309964

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tubulin alpha chain

NP_001251212.1

Confirmed by transcript evidence

NP_001379189.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9785781..9787624 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392888.1 → NP_001379189.1 Tubulin alpha chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O18688, Q17409

Conserved Domains (1) summary

PTZ00335
Location:1 → 437

PTZ00335; tubulin alpha chain; Provisional
NM_001264283.3 → NP_001251212.1 Tubulin alpha chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251212.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2E8, Q17409

Conserved Domains (2) summary

PTZ00335
Location:6 → 442

PTZ00335; tubulin alpha chain; Provisional

cd02186
Location:7 → 438

alpha_tubulin; The alpha-tubulin family