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    psd-1 Phosphatidylserine decarboxylase beta chain [ Caenorhabditis elegans ]

    Gene ID: 176027, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psd-1
    Official Full Name
    Phosphatidylserine decarboxylase beta chain
    Primary source
    WormBase:WBGene00015159
    Locus tag
    CELE_B0361.5
    See related
    AllianceGenome:WB:WBGene00015159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylserine decarboxylase activity. Predicted to be involved in lipid droplet formation and phosphatidylethanolamine biosynthetic process. Predicted to be located in lipid droplet. Predicted to be active in mitochondrion. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See psd-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (7268416..7275396, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Major sperm protein Neighboring gene Peptidase metallopeptidase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Putative methyltransferase B0361.6 Neighboring gene Putative transporter B0361.11 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease. Wang S, et al. PLoS One, 2016. PMID 27736935, Free PMC Article
    2. Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease. Wang S, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25201965, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid droplet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatidylserine decarboxylase beta chain
    NP_001021127.1
    • Confirmed by transcript evidence
    NP_001021128.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7268416..7275396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025957.6 → NP_001021128.1  Phosphatidylserine decarboxylase beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10949, Q6AHR5
      Conserved Domains (1) summary
      cl03656
      Location:142 → 372
      PS_Dcarbxylase; Phosphatidylserine decarboxylase

    2. NM_001025956.6 → NP_001021127.1  Phosphatidylserine decarboxylase beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10949
      Conserved Domains (1) summary
      cl03656
      Location:113 → 343
      PS_Dcarbxylase; Phosphatidylserine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10949.2

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