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    • Showing Current items.

    hasp-1 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 172462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hasp-1
    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00007258
    Locus tag
    CELE_C01H6.9
    See related
    AllianceGenome:WB:WBGene00007258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables G-protein alpha-subunit binding activity. Predicted to be involved in intracellular signal transduction and mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in PHB; PVT; head neurons; intestine; and seam cell. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hasp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (7229429..7233121, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Metal transporter cnnm-4 Neighboring gene Bromo domain-containing protein Neighboring gene Secreted protein;Sensitive to high expression protein 9, mitochondrial Neighboring gene BEN domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of Caenorhabditis elegans Haspin-like genes shows that hasp-1 plays multiple roles in the germline. Macaraeg J, et al. Biol Open, 2022 Jul 15. PMID 35678140, Free PMC Article
    2. Proteins interacting with Caenorhabditis elegans Galpha subunits. Cuppen E, et al. Comp Funct Genomics, 2003. PMID 18629017, Free PMC Article
    3. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone H3T3 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_492043.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7229429..7233121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059642.7 → NP_492043.2  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492043.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE25
      Conserved Domains (1) summary
      pfam12330
      Location:615 → 893
      Haspin_kinase; Haspin like kinase domain
    Nucleotide Protein
    Heading Accession and Version

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