best-1 Bestrophin homolog 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: best-1
Official Full Name: Bestrophin homolog 1
Primary source: WormBase:WBGene00007203
Locus tag: CELE_B0564.3
See related: AllianceGenome:WB:WBGene00007203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable bicarbonate channel activity and intracellularly calcium-gated chloride channel activity. Predicted to be involved in protein complex oligomerization; regulation of synaptic plasticity; and secretion by cell. Predicted to be located in membrane microdomain and plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human BEST2 (bestrophin 2) and BEST4 (bestrophin 4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables bicarbonate channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly calcium-gated chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid secretion, neurotransmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamate secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in membrane microdomain	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

NP_502523.1

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The following sections contain reference sequences that belong to a specific genome build. Explain