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    dhs-20 Retinol dehydrogenase 7 [ Caenorhabditis elegans ]

    Gene ID: 179590, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dhs-20
    Official Full Name
    Retinol dehydrogenase 7
    Primary source
    WormBase:WBGene00000983
    Locus tag
    CELE_F35B12.2
    See related
    AllianceGenome:WB:WBGene00000983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in steroid metabolic process. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13; fundus albipunctatus; and night blindness. Orthologous to several human genes including DHRS9 (dehydrogenase/reductase 9); HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); and RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See dhs-20 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (11602294..11604563, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene Spindle assembly abnormal protein 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. D-beta-hydroxybutyrate extends lifespan in C. elegans. Edwards C, et al. Aging (Albany NY), 2014 Aug. PMID 25127866, Free PMC Article
    2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Retinol dehydrogenase 7
    NP_505941.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11602294..11604563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073540.6 → NP_505941.3  Retinol dehydrogenase 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505941.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20012
      Conserved Domains (2) summary
      pfam00106
      Location:42 → 230
      adh_short; short chain dehydrogenase
      cl21454
      Location:42 → 321
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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